Establishment of a long-term chick forebrain neuronal culture on a microelectrode array platform
نویسندگان
چکیده
منابع مشابه
A Novel Polymeric Microelectrode Array for Highly Parallel , Long - Term Neuronal Culture and Stimulation
Cell-based high-throughput screening is emerging as a disruptive technology in drug discovery; however, massively parallel electrical assaying of neurons and cardiomyocites has until now been prohibitively expensive. To address this limitation, we developed a scalable, all-organic 3D microelectrode array technology. The cheap, disposable arrays would be integrated into a fixed stimulation and i...
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High-throughput cell-based screening has recently been emerging as a feasible technology for drug testing and discovery. However, currently available tools for electrical assaying are expensive, have limited reproducibility, and are unable to sustain long term studies. The Bioinstrumentation Laboratory at the Massachusetts Institute of Technology has developed a novel, 3D MEA for use in long te...
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Microelectrode arrays and microprobes have been widely utilized to measure neuronal activity, both in vitro and in vivo. The key advantage is the capability to record and stimulate neurons at multiple sites simultaneously. However, unlike the single-cell or single-channel resolution of intracellular recording, microelectrodes detect signals from all possible sources around every sensor. Here, w...
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We report on the system integration of a CMOS chip that is capable of bidirectionally communicating (stimulation and recording) with electrogenic cells such as neurons or cardiomyocytes and that is targeted at investigating electrical signal propagation within cellular networks in vitro. The overall system consists of three major subunits: first, the core component is a 6.5 mm x 6.5 mm CMOS chi...
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ژورنال
عنوان ژورنال: RSC Advances
سال: 2015
ISSN: 2046-2069
DOI: 10.1039/c5ra09663d